BDBM380448 4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,1′H-4,4′-bipyrazol-1-yl]azetidin-1-yl}-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide trifluoroacetate::US10435392, Example 12::US9926301, Example 12

SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1CO)C(F)(F)F

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380448   

TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM380448(4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,...)
Affinity DataIC50:  650nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM380448(4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM380448(4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,...)
Affinity DataIC50:  650nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM380448(4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,...)
Affinity DataIC50: >700nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent