BDBM38115 3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(phenylsulfonyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-1H-indole-2-carboxamide::US10093640, Example 102::US10844032, Example 102

SMILES Cc1cc(OCCCc2c([nH]c3c(cccc23)-c2ncccc2C(F)(F)F)C(=O)NS(=O)(=O)c2ccccc2)cc(C)c1Cl

InChI Key InChIKey=GFNFCKXMBRCZGG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 38115   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [172-327](Homo sapiens (Human))
Vanderbilt University

US Patent
LigandPNGBDBM38115(3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(phen...)
Affinity DataKi: <100nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38115(3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-N-(phen...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In DepthDetails US Patent