BDBM384147 (1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)methanamine::US10280171, Example 33::US10851110, Example 33::US11466017, Example 33

SMILES COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1

InChI Key InChIKey=XEMDEEZOTNHZCZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 384147   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384147((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...)
Affinity DataIC50:  72nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384147((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...)
Affinity DataIC50:  72nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384147((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...)
Affinity DataIC50:  72nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384147((1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b...)
Affinity DataIC50:  96nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent