BDBM384152 (S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]-decan-4-amine::US10280171, Example 38::US10851110, Example 38::US11466017, Example 38

SMILES N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 384152   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  75nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  40nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  75nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  100nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  12nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384152((S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]py...)
Affinity DataIC50:  75nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent