BDBM384192 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 112::US10851110, Example 112::US11466017, Example 112

SMILES CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(N)CC2)c1Cl

InChI Key InChIKey=XLKDUTBYZJONNW-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 384192   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  128nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  58nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  128nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  53nMAssay Description:Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluoro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384192(4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[...)
Affinity DataIC50:  128nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB