BDBM384198 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4(aminomethyl)piperidin-4-ol::US10280171, Example 118::US10851110, Example 118::US11466017, Example 118

SMILES CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl

InChI Key InChIKey=NRGYUJKDKQWLQO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 384198   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384198(1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,...)
Affinity DataIC50:  1.13E+3nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384198(1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,...)
Affinity DataIC50:  1.13E+3nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384198(1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,...)
Affinity DataIC50:  1.13E+3nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384198(1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,...)
Affinity DataIC50:  8.28E+3nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent