BDBM388978 4-(8-(5-chloro-6-methylpyridin-3- yl)-5-{[(3R)-1-methylpiperidin-3- yl]methoxy}imidazo[1,2- c]pyrimidin-7-yl)benzonitrile::US10800779, Example 92::US11401272, Example 92::US9944647, Example 92

SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cnc(C)c(Cl)c3)c3nccn23)C1

InChI Key InChIKey=KHAZLMZDIXJTBI-LJQANCHMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 388978   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM388978(4-(8-(5-chloro-6-methylpyridin-3- yl)-5-{[(3R)-1-m...)
Affinity DataIC50: <50nMAssay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM388978(4-(8-(5-chloro-6-methylpyridin-3- yl)-5-{[(3R)-1-m...)
Affinity DataIC50: <50nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM388978(4-(8-(5-chloro-6-methylpyridin-3- yl)-5-{[(3R)-1-m...)
Affinity DataIC50: <50nMAssay Description:LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent