BDBM389001 4-{5-[(3R)-3- (dimethylamino)pyrrolidin-1-yl]-8- [3-fluoro-4-(hydroxymethyl)-5- methylphenyl]imidazo[1,2- c]pyrimidin-7-yl}benzonitrile::US10800779, Example 110::US11401272, Example 110::US9944647, Example 110

SMILES CN(C)[C@@H]1CCN(C1)c1nc(-c2ccc(cc2)C#N)c(-c2cc(C)c(CO)c(F)c2)c2nccn12

InChI Key InChIKey=IDNVKYDKIJKNEQ-OAQYLSRUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 389001   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM389001(4-{5-[(3R)-3- (dimethylamino)pyrrolidin-1-yl]-8- [...)
Affinity DataIC50: <50nMAssay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM389001(4-{5-[(3R)-3- (dimethylamino)pyrrolidin-1-yl]-8- [...)
Affinity DataIC50: <50nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM389001(4-{5-[(3R)-3- (dimethylamino)pyrrolidin-1-yl]-8- [...)
Affinity DataIC50: <50nMAssay Description:LANCE LSD1/KDM1A demethylase assay—10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent