BDBM392575 N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-3-cyano-1-((3-methyl-8- (methylsulfonyl)quinolin-6- yl)methyl)-1H-pyrazole-4- carboxamide::US10301284, Example 61::US10781200, Example 61

SMILES Cc1cnc2c(cc(Cn3cc(C(=O)NCc4c(C)cc(N)nc4C)c(n3)C#N)cc2c1)S(C)(=O)=O

InChI Key InChIKey=XPRAOLSTLRFCRV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392575   

TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM392575(N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-3-cy...)
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM392575(N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-3-cy...)
Affinity DataIC50: <100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent