BDBM392580 N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-5-cyano-1-((8-(2- hydroxypropan-2-yl)-3- methylquinolin-6-yl)methyl)-1H- pyrazole-4-carboxamide::US10301284, Example 67::US10781200, Example 67

SMILES Cc1cnc2c(cc(Cn3ncc(C(=O)NCc4c(C)cc(N)nc4C)c3C#N)cc2c1)C(C)(C)O

InChI Key InChIKey=VGEXEBFWUMODSQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 392580   

TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM392580(N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-5-cy...)
Affinity DataIC50:  5.50E+3nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM392580(N-((6-amino-2,4-dimethylpyridin-3- yl)methyl)-5-cy...)
Affinity DataIC50:  5.50E+3nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent