BDBM394334 US10428087, Example 54::US10829502, Example 54::US11401280, Example 54::US9975907, Example 54

SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(Cl)c1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 394334   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM394334(US10428087, Example 54 | US10829502, Example 54 | ...)
Affinity DataIC50: <50nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM394334(US10428087, Example 54 | US10829502, Example 54 | ...)
Affinity DataIC50: <50nMAssay Description:PI3Kα, PI3Kβ, PI3Kγ: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM394334(US10428087, Example 54 | US10829502, Example 54 | ...)
Affinity DataIC50: <50nMAssay Description:Example A3: The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM394334(US10428087, Example 54 | US10829502, Example 54 | ...)
Affinity DataIC50: <50nMAssay Description:Assay A2: The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent