BDBM395717 4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-2-fluorobenzamide::US10308648, Compound 112::US10865206, Compound 112

SMILES Nc1ccc(C(=O)N[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395717   

TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Syros Pharmaceuticals

US Patent
LigandPNGBDBM395717(4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)py...)
Affinity DataIC50:  550nMAssay Description:Compounds of the invention were assayed for CDK7 activity at Life Technologies(Grand Island, N.Y.) using their commercially available AdaptaŽ kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Syros Pharmaceuticals

US Patent
LigandPNGBDBM395717(4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)py...)
Affinity DataIC50:  550nMAssay Description:Compounds of the invention were assayed for CDK7 activity at Life Technologies (Grand Island, N.Y.) using their commercially available Adapta kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent