BDBM399678 US10323036, Compound I-122::US10793574, Compound I-122::US11220508, Compound I-122

SMILES COc1c(Nc2cc(Nc3cccc(n3)C#N)nc3[nH]n(C)c(=O)c23)cccc1-c1ccn(C)n1

InChI Key InChIKey=OQPKEADTUJMELQ-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 399678   

TargetNon-receptor tyrosine-protein kinase TYK2 [V731I](Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM399678(US10323036, Compound I-122 | US10793574, Compound ...)
Affinity DataKd:  0.300nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM399678(US10323036, Compound I-122 | US10793574, Compound ...)
Affinity DataKd:  0.300nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshmi

US Patent
LigandPNGBDBM399678(US10323036, Compound I-122 | US10793574, Compound ...)
Affinity DataKd:  0.300nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent