BDBM402284 (N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)methyl)benzamide)::US10011611, RBC-3001-A

SMILES ONC(=O)c1ccc(Cn2sc3ncccc3c2=O)cc1

InChI Key InChIKey=VLJAVCKTTLIBDT-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 402284   

TargetHistone deacetylase 1(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  175nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  5.40E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 [395-489](Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  1.31E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [627-1085](Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  3.31E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  508nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 11(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  2.84E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 7 [518-592](Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  1.89E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  27.1nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9 [604-1066](Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  1.41E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  4.26E+3nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Reaction Biology

US Patent
LigandPNGBDBM402284((N-hydroxy-4-((3-oxoisothiazolo[5,4-b]pyridin-2(3H...)
Affinity DataIC50:  0.958nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent