BDBM411504 (R)-1-(1-((6-(3- methylmorpholino)-2- (1H-pyrrolo[2,3-b]- pyridin-4-yl)pyrimidin-4- yl)imino)-1-oxido-1lambda6- thiomorpholino)propan- 1-one::US10392376, Example 55::US10800769, Example 55::US11434233, Example 55

SMILES CCC(=O)N1CCS(=O)(CC1)=Nc1cc(nc(n1)-c1ccnc2[nH]ccc12)N1CCOC[C@H]1C

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411504   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411504((R)-1-(1-((6-(3- methylmorpholino)-2- (1H-pyrrolo[...)
Affinity DataIC50:  4nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411504((R)-1-(1-((6-(3- methylmorpholino)-2- (1H-pyrrolo[...)
Affinity DataIC50:  4nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411504((R)-1-(1-((6-(3- methylmorpholino)-2- (1H-pyrrolo[...)
Affinity DataIC50:  61nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411504((R)-1-(1-((6-(3- methylmorpholino)-2- (1H-pyrrolo[...)
Affinity DataIC50:  4nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent