BDBM416498 1-cyclopropyl-2-(4-(difluoromethoxy)benzyl)-N-(4-(ethylsulfonyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide::US10301261, Compound BE-48::US10829448, Compound BE-48

SMILES CCS(=O)(=O)c1ccc(CNC(=O)c2ccc3n(C4CC4)c(Cc4ccc(OC(F)F)cc4)nc3c2)cc1

InChI Key InChIKey=WBBYFGBCPDCNIO-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 416498   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM416498(1-cyclopropyl-2-(4-(difluoromethoxy)benzyl)-N-(4-(...)
Affinity DataKi: <100nMAssay Description:Compounds described herein were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-ligand (RL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM416498(1-cyclopropyl-2-(4-(difluoromethoxy)benzyl)-N-(4-(...)
Affinity DataKi: <100nMAssay Description:Compounds described herein were tested for ability to bind to RORγ in a cell-free competition assay with commercially available radio-ligand (RL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM416498(1-cyclopropyl-2-(4-(difluoromethoxy)benzyl)-N-(4-(...)
Affinity DataIC50: <100nMAssay Description:Compounds described herein were tested for RORγ inverse agonist activity in a cell-based, transcriptional activity assay. Secreted NanolucŪ luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent