BDBM421539 3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)indole-6-sulfonamide::US10508086, Example 129

SMILES Cc1nnc(s1)-n1cc(Cc2sc(C)nc2C)c2ccc(cc12)S(=O)(=O)NC1(C)CC1

InChI Key InChIKey=JARZVIBTIBGCGT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 421539   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421539(3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcy...)
Affinity DataEC50:  371nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421539(3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcy...)
Affinity DataIC50: >1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM421539(3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcy...)
Affinity DataIC50: >1.67E+4nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent