BDBM423206 (R)-4-methoxy-6-(4- ((3-(4-methyl-1-oxo-1,3- dihydroisobenzofuran- 5-yl)piperazin-1-yl) methyl)-1H-pyrazol-1-yl) nicotinonitrile::US10501449, Example 59-I

SMILES COc1cc(ncc1C#N)-n1cc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=BNSMCPQFZIYLEG-NRFANRHFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 423206   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423206((R)-4-methoxy-6-(4- ((3-(4-methyl-1-oxo-1,3- dihyd...)
Affinity DataIC50:  4.80nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent