BDBM423287 US10501451, Example 12, P-1::US10501451, Example 12, P-2::US10954225, Example 12,P-2

SMILES Oc1ccc(cc1)[C@@H]1CCN(C[C@H]1F)C1CCON(Cc2ccc(Cl)cc2)C1=O

InChI Key InChIKey=FPMFDMCHCNBOAE-MCOCGALXSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 423287   

TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423287(US10501451, Example 12, P-1 | US10501451, Example ...)
Affinity DataKi:  3.90nMAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423287(US10501451, Example 12, P-1 | US10501451, Example ...)
Affinity DataKi:  3.90nMAssay Description:Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423287(US10501451, Example 12, P-1 | US10501451, Example ...)
Affinity DataKi:  150nMAssay Description:To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 μg/well). The experimental co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM423287(US10501451, Example 12, P-1 | US10501451, Example ...)
Affinity DataKi:  150nMAssay Description:Binding experiments to determine binding to NR2B-subtype NMDA receptors were performed on forebrains of 8-10 weeks old male Sprague Dawley rats (Harl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent