BDBM423462 US11753373, Compound A-5-a::WO2006061714, P38.2::WO2006061714-ID-04

SMILES COc1cccc2[nH]c(cc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C=O

InChI Key InChIKey=QCRLRBSKQJIUTG-MPGHIAIKSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 423462   

TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataEC50:  1.40E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(SARS coronavirus Urbani)
Pfizer

WIPO
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataEC50:  1.40E+6nMAssay Description:Proteolytic activity of Coronavirus 3C protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS 3CI_pro FRET as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  3.18nMAssay Description:Mpro activity was measured according to the manufacturer's protocol (BPS Biosciences, cat #78042-2) in 384-well plates. The included recombinant un-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423462(US11753373, Compound A-5-a | WO2006061714, P38.2 |...)
Affinity DataIC50:  60nMAssay Description:Inhibition of SARS-CoV-2 3CL protease by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed