BDBM426379 US10526325, Compound A55::US10829489, Compound A55::US11261185, Example 55

SMILES C[C@H]1CN(Cc2cnc(-c3ccc(F)cc3F)n12)C(=O)[C@@](C)(O)C(F)(F)F

InChI Key InChIKey=RDLMYQJAEROHOM-XXFAHNHDSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 426379   

LigandPNGBDBM426379(US10526325, Compound A55 | US10829489, Compound A5...)
Affinity DataIC50:  1.65E+3nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter. In general titrations were performed by titrating the protein (50 μM) to the te...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM426379(US10526325, Compound A55 | US10829489, Compound A5...)
Affinity DataIC50:  1.65E+3nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM426379(US10526325, Compound A55 | US10829489, Compound A5...)
Affinity DataIC50:  1.65E+3nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent