BDBM429667 US10550091, No. LC-76::US10947203, No. LC-76

SMILES COc1ccc(OC)c(c1)-c1nc(C)c(n1C)S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=ITWHJOFOMZLYFK-UHFFFAOYSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 429667   

TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429667(US10550091, No. LC-76 | US10947203, No. LC-76)
Affinity DataIC50:  140nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429667(US10550091, No. LC-76 | US10947203, No. LC-76)
Affinity DataEC50:  2.80E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429667(US10550091, No. LC-76 | US10947203, No. LC-76)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429667(US10550091, No. LC-76 | US10947203, No. LC-76)
Affinity DataEC50:  2.80E+3nMAssay Description:The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429667(US10550091, No. LC-76 | US10947203, No. LC-76)
Affinity DataIC50:  2.10E+3nMAssay Description:Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
St. Jude Children''S Research Hospital

US Patent
LigandPNGBDBM429667(US10550091, No. LC-76 | US10947203, No. LC-76)
Affinity DataIC50:  140nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent