BDBM4304 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide::CHEMBL56731::cid_5328771::tyrphostin 1

SMILES Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O

InChI Key InChIKey=HKHOVJYOELRGMV-XYOKQWHBSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 4304   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  700nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.00E+4nMAssay Description:The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge T antigen(Simian virus 40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataEC50: >5.00E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Bos taurus (Bovine))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  6.79E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  4.17E+4nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(RAT)
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  9.00E+4nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of ERBB2 receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed