BDBM431046 6-[3-(hydroxymethyl)-4-[(3-[[(2S)-[[6-oxo-5-(trifluoromethyl)-1,6-dihydropyridazin-4-yl]pyrrolidin-2-yl]methoxy]phenyl)carbonyl]piperazin-1-yl]pyridine-3-carbonitrile::US10550105, Example 33::US10870641, Example 33::US11014913, Example 33

SMILES OCC1CN(CCN1C(=O)c1cccc(OC[C@@H]2CCCN2c2cn[nH]c(=O)c2C(F)(F)F)c1)c1ccc(cn1)C#N

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 431046   

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431046(6-[3-(hydroxymethyl)-4-[(3-[[(2S)-[[6-oxo-5-(trifl...)
Affinity DataIC50: <100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431046(6-[3-(hydroxymethyl)-4-[(3-[[(2S)-[[6-oxo-5-(trifl...)
Affinity DataIC50: <100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Ribon Therapeutics

US Patent
LigandPNGBDBM431046(6-[3-(hydroxymethyl)-4-[(3-[[(2S)-[[6-oxo-5-(trifl...)
Affinity DataIC50: <100nMAssay Description:Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent