BDBM441828 US10647665, Example 1-15::US10851050, Example I-15
SMILES OC(=O)Cc1ccc(CNC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
InChI Key InChIKey=ZBAVYJYWRYFFEJ-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 441828
Affinity DataIC50: <500nMAssay Description:1. Preparation of RORgamma Buffer Solution10 mL of DTT and 100 mL buffer solution were gently mixed together and ready to use.2. Preparation of Compo...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:The inhibitory activity of compounds on RORγ receptor was determined by fluorescence resonance energy transfer (FRET) experiments. The inhibitor...More data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inverse agonist activity at human ROR-gammat LBD expressed in HEK293T cells assessed as inhibition of RORgammat transcription by Gal4-luciferase repo...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inverse agonist activity at ROR-alpha (unknown origin) expressed in HEK293 cells by Gal4-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inverse agonist activity at ROR-beta (unknown origin) expressed in HEK293 cells by Gal4-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by...More data for this Ligand-Target Pair