BDBM442756 6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine::US10647727, Example 14

SMILES C[C@@H](N(C)c1nc(Cl)nc2n(C)ncc12)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=OPYMLAHVIILMAJ-SECBINFHSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442756   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442756(6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethy...)
Affinity DataKi:  65nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442756(6-Chloro-N,1-dimethyl-N-{(1R)-1-[4-(trifluoromethy...)
Affinity DataKi:  137nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent