BDBM442758 6-Chloro-N-ethyl-1- methyl-N-[4- (trifluoromethyl)- benzyl]-1H-pyrazolo- [3,4-d]pyrimidin- 4-amine::US10647727, Example 16

SMILES CCN(Cc1ccc(cc1)C(F)(F)F)c1nc(Cl)nc2n(C)ncc12

InChI Key InChIKey=YUCXOPXWJQTIRR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442758   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442758(6-Chloro-N-ethyl-1- methyl-N-[4- (trifluoromethyl)...)
Affinity DataKi:  429nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442758(6-Chloro-N-ethyl-1- methyl-N-[4- (trifluoromethyl)...)
Affinity DataKi:  866nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent