BDBM442771 N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cyclopropyl}-6-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::US10647727, Example 28

SMILES Cc1nc(NC2(CC2)c2ccc(c(F)c2)C(F)(F)F)c2cnn(CC(F)(F)F)c2n1

InChI Key InChIKey=BXGARXNOUZBAIQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442771   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442771(N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...)
Affinity DataKi:  76nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442771(N-{1-[3-Fluoro-4-(trifluoromethyl)phenyl]cycloprop...)
Affinity DataKi:  98nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent