BDBM444432 US10662159, Example 17
SMILES FC(F)(F)C(OC(=O)N1CCc2cc(Br)ccc2C1)C(F)(F)F
InChI Key InChIKey=QNNLSVRDDCVIGF-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 444432
Affinity DataIC50: 55nMAssay Description:ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:hABHD6:Initial Fluorescent Inhibition Assay (3-Point)—In each well of a 96-well plate 8 μL of membrane fraction containing full-length hABHD6 (1...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Rat/homo FAAH:Procedure was followed as described for hMGL, except that arachidonoyl-methyl coumarin (was used as fluorigenic substrate. Compounds we...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:MGL: Compound inhibition of hMGL activity was assessed by a fluorometric assay recently developed in our laboratory (Makriyannis et al WO Patent Appl...More data for this Ligand-Target Pair