BDBM444474 US10662159, Example 67::US10662159, Example 68
SMILES Fc1ccc(cc1)C(OC1CC2(C1)CCN(C2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1
InChI Key InChIKey=HAHQZQSTRNGLJE-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 444474
Affinity DataIC50: 55nMAssay Description:ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:MGL: Compound inhibition of hMGL activity was assessed by a fluorometric assay recently developed in our laboratory (Makriyannis et al WO Patent Appl...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Rat/homo FAAH:Procedure was followed as described for hMGL, except that arachidonoyl-methyl coumarin (was used as fluorigenic substrate. Compounds we...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:hABHD6:Initial Fluorescent Inhibition Assay (3-Point)—In each well of a 96-well plate 8 μL of membrane fraction containing full-length hABHD6 (1...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:MGL: Compound inhibition of hMGL activity was assessed by a fluorometric assay recently developed in our laboratory (Makriyannis et al WO Patent Appl...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Rat/homo FAAH:Procedure was followed as described for hMGL, except that arachidonoyl-methyl coumarin (was used as fluorigenic substrate. Compounds we...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:hABHD6:Initial Fluorescent Inhibition Assay (3-Point)—In each well of a 96-well plate 8 μL of membrane fraction containing full-length hABHD6 (1...More data for this Ligand-Target Pair