BDBM444676 (R)-1-(3-(5-acryloyl-3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-4,5,6,7- tetrahydro-1H-pyrazolo[4,3-c]pyridin-1- yl)pyrrolidin-1-yl)prop-2-en-1-one::US10662187, Compound 46::US10793566, Compound 46

SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c3CCN(Cc23)C(=O)C=C)c1F

InChI Key InChIKey=WSRFLJQUROETJM-HXUWFJFHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444676   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444676((R)-1-(3-(5-acryloyl-3-(4-(2-fluoro-3- methoxyphen...)
Affinity DataIC50: >1.00E+4nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444676((R)-1-(3-(5-acryloyl-3-(4-(2-fluoro-3- methoxyphen...)
Affinity DataIC50: >1.00E+4nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent