BDBM444681 (R)-1-(3-(3-(3-fluoro-4-phenoxyphenyl)- 1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin- 1-yl)prop-2-en-1-one::US10662187, Compound 51::US10793566, Compound 51

SMILES Fc1cc(ccc1Oc1ccccc1)-c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ccncc12

InChI Key InChIKey=ZBKWSXIOJWHZMN-LJQANCHMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444681   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444681((R)-1-(3-(3-(3-fluoro-4-phenoxyphenyl)- 1H-pyrazol...)
Affinity DataIC50:  55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444681((R)-1-(3-(3-(3-fluoro-4-phenoxyphenyl)- 1H-pyrazol...)
Affinity DataIC50:  55nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent