BDBM444685 (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)- 1H-indazol-1-yl)piperidin-1-yl)prop-2-en- 1-one::US10662187, Compound 55::US10793566, Compound 55

SMILES Nc1cccc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=UKSCBKJHLGMORO-HXUWFJFHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444685   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444685((R)-1-(3-(4-amino-3-(4-phenoxyphenyl)- 1H-indazol-...)
Affinity DataIC50:  55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444685((R)-1-(3-(4-amino-3-(4-phenoxyphenyl)- 1H-indazol-...)
Affinity DataIC50:  55nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent