BDBM444711 (R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)-7-ethoxy- 1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1- yl)prop-2-en-1-one::US10662187, Compound 81::US10793566, Compound 81

SMILES CCOc1cncc2c(nn([C@@H]3CCCN(C3)C(=O)C=C)c12)-c1ccc(Oc2cccc(OC)c2Cl)cc1

InChI Key InChIKey=BLMUPMRIQRWTIM-HXUWFJFHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444711   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444711((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Affinity DataIC50: <10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444711((R)-1-(3-(3-(4-(2-chloro-3- methoxyphenoxy)phenyl)...)
Affinity DataIC50: <10nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent