BDBM444734 (R)-4-(1-(1-acryloylpiperidin-3- yl)-1H-pyrazolo[4,3-c]pyridin-3- yl)-N-(3- methoxybenzyl)benzamide::US10662187, Compound 104::US10793566, Compound 104

SMILES COc1cccc(CNC(=O)c2ccc(cc2)-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ccncc23)c1

InChI Key InChIKey=UQNIDVWIHRMXFQ-HSZRJFAPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444734   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444734((R)-4-(1-(1-acryloylpiperidin-3- yl)-1H-pyrazolo[4...)
Affinity DataIC50:  550nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444734((R)-4-(1-(1-acryloylpiperidin-3- yl)-1H-pyrazolo[4...)
Affinity DataIC50:  550nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent