BDBM452999 (2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenzofuran-1-yl)-5- (4-methyl-7H-pyrrolo[2,3- d]pyrimidin-7- yl)tetrahydrofuran-3,4-diol::US10711007, Example 15::US11214574, Ex# 15::US11254683, Example 15

SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCc2ccc(Cl)cc12

InChI Key InChIKey=XLDLIFBOVZRYMG-WAXPSYRMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 452999   

TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM452999((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM452999((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM452999((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...)
Affinity DataIC50:  1nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent