BDBM462787 US10780090, Compound I-117::US10780090, Compound I-117a::US10780090, Compound I-117b::[(1R,2S,4R)-4-{[5-({4-[(1S)-1-(3-chlorophenyl)ethyl]-2-thienyl}carbonyl)pyrimidin-4- yl]amino}-2-hydroxycyclopentyl]methyl sulfamate

SMILES C[C@H](c1csc(c1)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1)c1cccc(Cl)c1

InChI Key InChIKey=VGYQRRZWURTPID-FSPMTTQMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 462787   

TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM462787(US10780090, Compound I-117 | US10780090, Compound ...)
Affinity DataIC50: <10nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM462787(US10780090, Compound I-117 | US10780090, Compound ...)
Affinity DataIC50: <10nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM462787(US10780090, Compound I-117 | US10780090, Compound ...)
Affinity DataIC50:  55nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent