BDBM462985 US10780090, Compound I-274::US10780090, Compound I-274a::US10780090, Compound I-274b::[(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-2- thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate

SMILES NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1cc(cs1)[C@@H]1NCCc2ccc(Cl)cc12

InChI Key InChIKey=VTYUOMASBKDZEV-RWDRWCIPSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 462985   

TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM462985(US10780090, Compound I-274 | US10780090, Compound ...)
Affinity DataIC50: <10nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM462985(US10780090, Compound I-274 | US10780090, Compound ...)
Affinity DataIC50:  55nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM462985(US10780090, Compound I-274 | US10780090, Compound ...)
Affinity DataIC50: <10nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent