BDBM463132 US10780090, Compound I-359a::US10780090, Compound I-359b::[(1R,2S,4R)-4-{[5-({4-[(1R)-6-chloro-1,3-dihydro-2-benzothiophen-1-yl]-5-methyl-2- thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate

SMILES Cc1sc(cc1[C@@H]1SCc2ccc(Cl)cc12)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1

InChI Key InChIKey=JRYLAISXLLQDNG-UYANQGCYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463132   

TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM463132(US10780090, Compound I-359a | US10780090, Compound...)
Affinity DataIC50: <10nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM463132(US10780090, Compound I-359a | US10780090, Compound...)
Affinity DataIC50:  55nMAssay Description:The SAE enzymatic reaction totals 50 μl and contains 50 mM HEPES Hemisodium (pH 7.5), 0.05% BSA, 5 mM MgCl2, 0.5 μM ATP, 250 μM GSH, 0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent