BDBM463158 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 12-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)c(F)c1

InChI Key InChIKey=DEJCTJFZLQNOON-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463158   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463158(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(...)
Affinity DataKi:  0.153nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent