BDBM463167 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(8- (cyclohexylmethyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 21-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)c(F)c1

InChI Key InChIKey=NKLSIMQSRCTBLT-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463167   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463167(4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(...)
Affinity DataKi:  0.206nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent