BDBM463233 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(8- (4,4,4-trifluorobutyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 87-A

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCCC(F)(F)F)n1)c1ccc(Cl)c(O)c1

InChI Key InChIKey=TXVJQFJVHKFYIJ-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463233   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463233(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(...)
Affinity DataKi:  2.80nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent