BDBM463257 4-Amino-2-{8-[(3- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]- pyrazin-6-yl}-5-(4- hydroxypyridin-2-yl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 110-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2cccc(F)c2)n1)c1cc(O)ccn1

InChI Key InChIKey=OIRIXNUNDGFLBX-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463257   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463257(4-Amino-2-{8-[(3- fluorophenyl)methyl]- [1,2,4]tri...)
Affinity DataKi:  1.62nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent