BDBM463258 4-Amino-5-(3-chloro-4- hydroxypyridin-2-yl)-2- {8-[(3,5-difluorophenyl)- methyl]imidazo[1,2-a]- pyrazin-6-yl}-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 111-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1nccc(O)c1Cl

InChI Key InChIKey=PJXOVGGYTDIWCO-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463258   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463258(4-Amino-5-(3-chloro-4- hydroxypyridin-2-yl)-2- {8-...)
Affinity DataKi:  1.74nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent