BDBM463261 4-Amino-5-(4-fluoro-3- hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)-[1,2,4]- triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H- pyrrolo(2,3-d]pyrimidin- 6-one::US10780092, Example 114-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1

InChI Key InChIKey=FVAYFZATNABPHP-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463261   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463261(4-Amino-5-(4-fluoro-3- hydroxyphenyl)-5- methyl-2-...)
Affinity DataKi:  4.95nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent