BDBM463265 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]- pyrazin-6-yl)-5-(4- hydroxypyridin-2-yl)- 5-methyl-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 118-B

SMILES CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)ccn1

InChI Key InChIKey=NQJKMCSIXXPDJA-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463265   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463265(4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]- pyrazi...)
Affinity DataKi:  7.95nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent