BDBM463275 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-5-methyl- 2-{8-[(3-methylphenyl)- methyl]imidazo[1,2-a]- pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 127-B

SMILES Cc1cccc(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(F)c2)c1

InChI Key InChIKey=XHTVPDMMQQROKG-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463275   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463275(4-Amino-5-(3-fluoro-4- hydroxyphenyl)-5-methyl- 2-...)
Affinity DataKi:  9.72nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent