BDBM463281 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}- 5-methyl-4-[(3,3,3- trifluoro-2-hydroxy- propyl)amino]-5,7- dihydro-6H-pyrrolo- [2,3-d]-pyrimidin-6-one::US10780092, Example 132-AA::US10780092, Example 132-AB

SMILES CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1

InChI Key InChIKey=YPWMLXNQOQBFMS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463281   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463281(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- ph...)
Affinity DataKi:  1.21nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463281(5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- ph...)
Affinity DataKi:  1.46nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent