BDBM463287 5-(4-Chloro-3-hydroxy- phenyl)-4-(4,4-difluoro- piperidin-1-yl)-2-{8-[(4- fluorophenyl)methyl]- imidazo[1,2-a]pyrazin-6- yl}-5-methyl-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 136-A

SMILES CC1(C(=O)Nc2nc(nc(N3CCC(F)(F)CC3)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1

InChI Key InChIKey=BPNLMMSCCGACBC-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463287   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463287(5-(4-Chloro-3-hydroxy- phenyl)-4-(4,4-difluoro- pi...)
Affinity DataKi:  1.57nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent