BDBM463298 4-amino-2-{8- (cyclohexylmethyl)- imidazo[1,2-a]pyrazin- 6-yl}-5-(4-hydroxy-5- (trifluoromethyl)pyridin- 2-yl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 147-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(cn1)C(F)(F)F

InChI Key InChIKey=DGXTZLOZTIAMKV-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463298   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463298(4-amino-2-{8- (cyclohexylmethyl)- imidazo[1,2-a]py...)
Affinity DataKi:  0.905nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent